Recombinant human NAMPT (rhNAMPT) protects human lung EC against TNF-α-induced EC apoptosis.
We have determined a novel new mechanism by which NAMPT regulates signaling pathways that influence major cellular fate decisions such as survival and programmed cell death. Our data clearly indicate that NAMPT-mediated effects on EC apoptosis are not triggered by iNAMPT-dependent NMN synthesis but rather involve eNAMPT secretion and subsequent