Nicotinamide Adenine Dinucleotide is an important biological molecule which is required for a healthy and long life. It was discovered back in 1906 as a coenzyme and since then, the molecule has been the target of scrutiny by scientists and biologists. In this article, we will address a very common question which is related to NAD+ that is: Why do the levels of NAD fall with age? Some suggest that it is due to the loss of Sirtuins proteins and their activity within the mitochondria or the powerhouse of the cell. While there are others who blame different components for the decline of NAD+. The decline of this molecule is the ultimate decline of metabolism which is why it is needed in an adequate amount. In order to probe into the deeper reasons of this decline, let us first understand what this molecule actually is.
What is NAD+?
Nicotinamide Adenine Dinucleotide exists in a minimized hydrogen version as well which is called NADH. Both of these versions are important coenzymes in the redox reactions. Some of the most important reactions occuring in the body (oxidative phosphorylation and catabolic Glycolysis) are undertaken by NAD itself. Recently, another important responsibility of Nicotinamide Adenine Dinucleotide has been uncovered which is the ‘signaling molecule’. This is a very old and crucial responsibility which includes sending signals to the intracellular components of the cell to make changes in the structure of functions. These adjustments guarantee energy metabolism, survival, well-being, cellular repair, syncing of all biological circadian rhythms and the usage of cellular energy. This signaling molecule is present in all living cells even the plants and bacterial cells. All the components of the cell can recognize and sense the signals made by the liposomal NAD+. The important components which turn the levels of NAD into signals are CtBPs, Sirtuin Deacylases and poly-ADP-ribose polymerases.
Unfortunately, these parts of cell can not continue to sense the fluctuations of NAD+ because it’s level gets reduced with the progression of age. Scientific research shows that by the time a person is 40, more than half of the NAD+ is decreased. If Nicotinamide Adenine Dinucleotide is decreased, it is obvious that Sirtuins proteins and other such molecules will lose their functionality as well.
is why the supplementation of NAD+ results in positive results which are
elongation of lifespan, enhanced insulin sensitivity and the restoration of
What causes the decline of NAD+?
The question which has bothered scientists for a long time has come to a plausible answer. This answer is that with age, Nicotinamide Adenine Dinucleotide stops its reproduction. Why does this happen? There are some factors which lead to the unfortunate reduction in the manufacturing of NAD+ which are agreed upon by all scientists. These factors include: The consumption of alcohol, sedentary lifestyle, sleep deprivation, exposure to the harmful ultraviolet radiation from the sun and being inactive. Having an unbalanced diet without the proper required nutrients is a strong factor as well. You can learn more at Alivebyscience NMN supplements section.